USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: DOK2_HUMAN USC-OGP 2-DE database:  DOK2_HUMAN DOK2_HUMAN General information about the entry View entry in simple text format Entry name DOK2_HUMAN Primary accession number O60496 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Docking protein 2; AltName: Full=Downstream of tyrosine kinase 2; AltName: Full=p56(dok-2);. Gene name Name=DOK2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0357: pI=5.34; Mw=51842 SPOT OGP-0438: pI=5.83; Mw=38391 Cross-references UniProtKB/Swiss-Prot O60496; DOK2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name DOK2_HUMAN Primary accession number O60496 Secondary accession number(s) Q8N5A4 Sequence was last modified on  March 6, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 145) Name and origin of the protein Description RecName: Full=Docking protein 2; AltName: Full=Downstream of tyrosine kinase 2; AltName: Full=p56(dok-2); Gene name Name=DOK2 Encoded on Name=DOK2 Keywords 3D-structure; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF034970; AAC13265.1; -; mRNA EMBL BC032623; AAH32623.1; -; mRNA CCDS CCDS6016.1; -; . RefSeq NP_003965.2; NM_003974.3; . UniGene Hs.71215; -; . PDB 2D9W; NMR; -; A=1-114 PDB 2DLW; NMR; -; A=148-247 PDBsum 2D9W; -; . PDBsum 2DLW; -; . ProteinModelPortal O60496; -; . SMR O60496; -; . BioGrid 114508; 37; . IntAct O60496; 8; . MINT MINT-1452945; -; . STRING 9606.ENSP00000276420; -; . iPTMnet O60496; -; . PhosphoSitePlus O60496; -; . BioMuta DOK2; -; . OGP O60496; -; . MaxQB O60496; -; . PaxDb O60496; -; . PeptideAtlas O60496; -; . PRIDE O60496; -; . DNASU 9046; -; . Ensembl ENST00000276420; ENSP00000276420; ENSG00000147443; . GeneID 9046; -; . KEGG hsa:9046; -; . UCSC uc003wzy.2; human; . CTD 9046; -; . DisGeNET 9046; -; . GeneCards DOK2; -; . HGNC HGNC:2991; DOK2; . HPA CAB004379; -; . MIM 604997; gene; . neXtProt NX_O60496; -; . OpenTargets ENSG00000147443; -; . PharmGKB PA27457; -; . eggNOG KOG4047; Eukaryota; . eggNOG ENOG410XS2S; LUCA; . GeneTree ENSGT00730000110348; -; . HOGENOM HOG000112245; -; . HOVERGEN HBG018962; -; . InParanoid O60496; -; . KO K20234; -; . OMA DWVQAIC; -; . OrthoDB EOG091G075T; -; . PhylomeDB O60496; -; . TreeFam TF324994; -; . Reactome R-HSA-210993; Tie2 Signaling; . Reactome R-HSA-8853659; RET signaling; . SignaLink O60496; -; . ChiTaRS DOK2; human; . EvolutionaryTrace O60496; -; . GeneWiki DOK2; -; . GenomeRNAi 9046; -; . PRO PR:O60496; -; . Proteomes UP000005640; Chromosome 8; . Bgee ENSG00000147443; -; . CleanEx HS_DOK2; -; . ExpressionAtlas O60496; baseline and differential; . Genevisible O60496; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005057; F:signal transducer activity; downstream of receptor; IEA:Ensembl GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc; . GO GO:0050900; P:leukocyte migration; TAS:Reactome; . GO GO:0007265; P:Ras protein signal transduction; IEA:Ensembl; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . GO GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Ensembl; . Gene3D 2.30.29.30; -; 2; . InterPro IPR002404; IRS_PTB; . InterPro IPR011993; PH_dom-like; . InterPro IPR001849; PH_domain; . Pfam PF02174; IRS; 1; . SMART SM00233; PH; 1; . SMART SM00310; PTBI; 1; . SUPFAM SSF50729; SSF50729; 2; . PROSITE PS51064; IRS_PTB; 1; . PROSITE PS50003; PH_DOMAIN; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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